The Interesting Connection Between Klebsiella Bacteria, Ankylosing Spondylitis, Crohns Disease and Stomach Cancer
Klebsiella Bacterium- It’s Relationship to Ankylosing Spondylitis, Crohns Disease, Stomach Ulcers and Stomach Cancer! And How a Low Starch Diet Effectively Treats All!
Dr. Art Ayers has a PhD in Molecular, Cellular and Developmental Biology. He subsequently held postdoctoral research positions at the Swedish Forest Products Research laboratories, Stockholm, U. Missouri – Columbia and Kansas State U.
He was an assistant Professor in the Cell and Developmental Biology Department at Harvard University and an associate professor and Director of the Genetic Engineering Program at Cedar Crest College in Allentown, PA. He joined the faculty at the College of Idaho in 1991 and in 97-98 he spent a six month sabbatical at the National University of Singapore. Recently his focusing on the role of heparin in inflammation and disease.
On October 12, 2009 Dr. Ayers wrote an article of interest especially to those with Ankylosing Spondylitis, Crohns Disease, and/or Stomach Cancer. This article discusses the Klebsiella P. bacterium, as well as the relationship between Klebsiella P. and Helicobacter Pylori (the bacteria known to cause stomach cancer and ulcers).
Helicobacter Pylori is well known for causing stomach ulcers and stomach cancer. It survives in the stomach by neutralizing stomach acid with ammonia. It has another interesting ability that allows it to survive this harsh environment. It has the capacity to use hydrogen gas that is dissolved in circulating blood as its energy source. Where does this hydrogen gas come from? It is produced by Klebsiella Pneumonia in gut biofilms.
Klebsiella P present in the gut has the ability to produce hydrogen gas, which has implications for bacteria such as H. Pylori which utilize and require hydrogen. If someone has an abundant source of hydrogen fuel in their blood, they are obviously a better target for H. Pylori colonization in the stomach.
Dr. Ayers says that “K. Pneumonia has been associated with Crohn’s Disease and Ankylosing Spondylitis”, and he goes on to explain the connection.
Klebsiella grows in gut biofilms (often resistant to antibiotics). As mentioned, it has the ability to produce hydrogen, but this is ONLY if it has enough fuel. It must have access to an adequate food source in order to expend the energy required to produce hydrogen. So what is the food source of Klebsiella? According to Dr. Ayers, it is “starch” in the diet.
When a human eats, their body produces enzymes that break down the food so it can be converted into energy. Similarly, when Klebsiella is exposed to starch, it produces an enzyme that can break down the starch to convert it into energy. The name of this particular enzyme it produces is Pullulanase. As Dr. Ayers explains “It turns out that the antigen causing Crohn’s Disease is the Pullulanse.”
Continuing on, Dr. Ayers also mentions that Klebsiella P. then produces Nitrogenase in order to use the energy it has received for the production of hydrogen. And of special interest to our AS community, he adds: “It is interesting that Nitrogenase is the antigen involved in Ankylosing Spondylitis.”
Therefore, “Klebsiella P. can only produce hydrogen with lots of glucose from starch”.
If we follow the chain of events, then, we see that eating starch leads to feeding the Klebsiella bacteria. Klebsiella utilizes the starch for food by producing an enzyme called Pullulanase (Pullulanase causes Crohns Disease). Once it has absorbed this energy from the starch, it then produces Nitrogenase to convert the energy into Hydrogen gas (Nitrogenase causes Ankylosing Spondylitis). The Hydrogen gas circulates in the blood stream and feeds the Pylori bacteria (which cause stomach ulcers and stomach cancer).
What are the implications of this discovery? Dr. Ayers goes on to mention that eating a low starch diet will starve out the Klebsiella P. bacteria. This would affectively halt the activity of Crohn’s Disease and Ankylosing Spondylitis, and would help to prevent an environment prime for the growth of stomach ulcers and stomach cancer.
To sum up the findings of Dr. Ayers, he says it best himself: “Inflammation is the foundation for cancer and degenerative autoimmune diseases. Small changes in diet and exercise, such as omega 3 oils, vitamin D, a low starch diet, and maintaining muscle mass, can dramatically alter predisposition to disease and aging and minimize the negative impact of genetic risks.”
Dr. Ayers has more than 190 articles available, including the one quoted from here, at http://CoolingInflammation.blogspot.com